Rob Howe’s Over-The-Counter T1D Challenge

Wait, who’s Rob? 

If you haven’t heard of Rob Howe, you’ve been missing out. His weekly podcast series, Diabetics Doing Things, is a testament to all things diabadass. Rob interviews people living with type one diabetes all around the globe, highlighting the amazingly astounding things they’re doing, while also living with diabetes. He’s covered over 1,000 years of living with T1D on his DDT podcast, and it’s just a side-gig of his! Now, Rob’s taking on another side-gig: his very own Over-The-Counter T1D Challenge.

Challenge Accepted

In other words, Rob is going all-in for a mini-documentary series where he’s going 100% on over-the-counter diabetes meds. As all of us living with diabetes know, diabetes medications and supplies are expensive. Unaffordably expensive, insurance or not. Rob felt, though, that while there’s plenty of documentation out there about living life with diabetes on insurance, there’s little to none regarding life without it, much less managing diabetes solely on over-the-counter supplies. So he’s changing that. Bring on #OverTheCounterT1DChallenge.

Back to Basics

For the next 30 days, Rob Howe will be using only R (short-acting)and NPH (intermediate-acting) insulins (along with syringes) for any and all insulin dosing, as these insulins are available without a prescription or insurance. Usually hooked up to his Medtronic Paradigm 24/7, Rob is cutting the cord ✂️

He’ll also be checking his blood sugar with his One Drop | Chrome meter and test strips, which are also available without prescription or insurance. He’ll also have the ability to check in with his One Drop | Expert on his One Drop app in case he needs any info or feedback for his new regimen.

End game 

The result? We’ll see! But it’s a pretty radical attempt to treat diabetes for an out-of-pocket cost less than $150 US per month. And we can all follow along every single day! Keep an eye on Rob’s Instagram Stories and his Diabetics Doing Things YouTube channel for all the real-time updates.

We are (un)pumped to see what he finds 😆

One Drop Store

The A-One Clinical Trial Has Launched!

Afrezza + One Drop

Study will utilize Afrezza inhaled insulin and the One Drop digital diabetes care platform

Last May, MannKind (maker of Afrezza) and One Drop announced a collaboration to focus on three consumer areas:

1. Access, Cost Savings and Convenience initiatives, intended to simplify the complexity of starting and staying on mealtime insulin.

2. Customized Coaching and Engagement designed to help people on Afrezza achieve the American Diabetes Association (ADA) recommendation of an A1C goal of less than 7%.

3. Design Innovation around packaging and exploration of a reusable Afrezza Inhaler with integrated Bluetooth technology.

Today, One Drop and Mannkind launched a study to evaluate the effectiveness of One Drop | Premium (i.e., One Drop | Mobile app, One Drop | Chrome meter and test strips, One Drop | Experts coaching service) and Afrezza (MannKind’s inhaled rapid-acting mealtime insulin) when used together.

 

Afrezza + One Drop

 

Interested in participating? Learn more here.

People with type 2 diabetes who meet inclusion criteria will be randomized to one of two treatment arms: Afrezza with One Drop | Premium – or – One Drop | Premium alone. Changes in hemoglobin A1C, quality of life, self-care, treatment satisfaction, and other metrics will be assessed.

 

ONE DROP | MOBILE APP WITH ONE DROP | EXPERTS ON IPHONE AND APPLE WATCH LOWERS A1C BY 1.2% IN 3 MONTHS

One Drop | Experts + Apple Watch

Company announces study results demonstrating a 1.2% absolute reduction in A1c among people with type 2 diabetes using One Drop | Mobile with One Drop | Experts personalized diabetes coaching on iPhone and Apple Watch

New York, NY — September 7, 2017 — One Drop will present real-world data from an evaluation of One Drop | Experts with the Apple Watch at the Stanford Medicine X Conference next week. Using retrospective app-collected data, the company will report peer-reviewed drastic improvements in self-care and blood glucose among people with type 2 diabetes (T2D). Specifically, people with type 2 diabetes and A1c levels equal to or greater than 7.5% who used the One Drop | Mobile app with One Drop | Experts on iPhone and Apple Watch for three months saw a 1.2% absolute reduction in A1C. See abstract for additional details.

One Drop is a free, award-winning, cloud-based diabetes management solution available on iOS, watchOS, Android, and Amazon Alexa. On iOS and Android, the One Drop | Mobile app allows people to store and track self-care behaviors (including blood glucose checks, medication doses, physical activity and food intake) manually and passively via the One Drop | Chrome Bluetooth-connected glucose meter, as well as thousands of other health tracking devices and apps through Apple HealthKit and Google Fit. The fully-featured watchOS app allows users to track the same self-care data, and view data-driven insights and statistics, right on their Watch face.

One Drop | Experts is an ADA-recognized diabetes education* and coaching service delivered entirely through the One Drop | Mobile app. The “Experts” are Certified Diabetes Educators available 24/7 for guidance, support, and anytime care. Experts deliver personalized digital therapeutics programs to help people with diabetes define and achieve their health management goals. Users can communicate with their Experts anytime via in-app chat; all data recorded in the app is available to Experts in real-time, allowing them to provide personalized behavioral guidance when it’s most relevant. One Drop is also the only diabetes management platform that offers comprehensive self-care, peer-support, and expert support all in one place.

Last year, Evidation Health Inc. recruited 144 U.S. adults with T2D to complete a survey, receive an Apple Watch, and use the One Drop | Mobile app on iOS and watchOS in combination with the One Drop | Experts program. Using real-world, app-tracked data, One Drop found improvements in:

• Weekly physical activity: +35 minutes

• Carbohydrate intake per meal: -20 grams

• Average blood glucose: -35 mg/dL (a -1.2% A1c reduction)

Evidation Health Inc. recruited an additional 146 people to use the One Drop | Experts program with the One Drop | Mobile app on iOS only (without an Apple Watch). Results presented at the 77th Scientific Sessions of the American Diabetes Association included an A1c improvement of -0.90% among study completers and -1.00% among active users [1]. Leveraging app-collected data, One Drop reported these same users improved, but not to the same degree as Apple Watch users [2]:

• Weekly physical activity: +25 minutes

• Carbohydrate intake per meal: -15 grams

• Average blood glucose: -29 mg/dL (a 1.00% A1c reduction)

“Evaluating whether we’re moving the needle and affecting health outcomes is critical at One Drop,” says Jeff Dachis, CEO and Founder of One Drop. “We’re harnessing real-world data to understand One Drop’s impact. So far, outcomes are consistent, compelling, and enhanced by the Apple Watch.”

The U.S. Food and Drug Administration just released final guidance on real-world data, which can be user-generated in an app like One Drop. According to the FDA document, when data is relevant and reliable, it may constitute valid scientific evidence.

“Our goals at One Drop are to improve the health of our users and to give them an incredible experience while they do it. At this intersection, we achieve meaningful outcomes,” says Dr. Chandra Osborn, Vice President of Health and Behavioral Informatics at One Drop. “With the help of Apple, we combine relevant and reliable passively-collected data, manually-entered data collected from our app, and objective glucose data from our meter, and we analyze all of them with the rigorous standards of scientific excellence.”

1 Kumar S., et al. Impact of a diabetes mobile app with in-app coaching on glycemic control. Late-breaking peer-reviewed poster presentation at the 77th Annual Meeting of the American Diabetes Association; San Diego, CA, USA, June 2017.
2 Osborn C.Y., et al The One Drop mobile app with in-app coaching improves blood glucose and self-care. Peer-reviewed poster presentation at the 77th Annual Meeting of the American Diabetes Association; San Diego, CA, USA, June 2017.

ABOUT ONE DROP

One Drop (Informed Data Systems Inc.) is a digital health company harnessing the power of mobile computing and data science to transform the lives of everyone with diabetes worldwide.

The One Drop platform is evidence-based and clinically effective. It brings affordable, accessible diabetes care to everyone with diabetes and a smartphone, as well as their insurers and health care providers. One Drop | Chrome is sold exclusively by One Drop (iOS, Android, and http://onedrop.today/), Amazon (http://www.amazon.com), and Apple (http://store.apple.com). One Drop’s consumer subscription services are available for purchase in-app (iOS and Android) and at http://onedrop.today. The One Drop | Mobile solution is available for free download worldwide (iOS and Android). For more information, contact just@onedrop.today.

*The American Diabetes Association recognizes this education service as meeting the National Standards for Diabetes Self-Management Education and Support. Learn more at http://www.onedrop.today.

ONE DROP LAUNCHES POWER OF 10 PROGRAM TO PROVIDE FREE ADA-RECOGNIZED DIABETES EDUCATION AND SUPPORT TO THOSE MOST IN NEED

For every One Drop subscription sold, One Drop is donating 10 One Drop | Experts subscriptions for its ADA-Recognized diabetes support and education program

New York, NY — September 6, 2017 — One Drop today announced the Power of 10, a charitable giving program where, for every One Drop subscription sold, One Drop is donating 10 subscriptions to One Drop | Experts, its ADA-Recognized digital diabetes support and education* program, to medically underserved and uninsured people with diabetes.

Today, over 30 million Americans are living with diabetes and another 90 million are living with prediabetes. It remains the 7th leading cause of death in the United States and takes a particularly hard toll on the “diabetes belt” — an area spanning 15 states in the Southeast with high rates of poverty, low levels of college educational attainment, and the highest rates of diabetes and obesity in the country. Access to quality healthcare is a major problem for people in these areas, as well as many other Americans who are currently underinsured, without health insurance, or otherwise medically underserved.

“Our patients have limited resources and time for diabetes management,” said Parker Panovec, MD, Medical Director of Faith Family Medical Center. “We are excited about the prospect of One Drop’s Power of 10 program and its potential to improve diabetic control and the lives of our patients.”

“Every 6 seconds a person dies from diabetes and the medically underserved are the worst hit,” said Jeff Dachis, CEO and Founder of One Drop. “Diabetes itself is not a death sentence. It is a manageable condition and many of these deaths can be prevented with better diabetes education. Through the Power of 10, One Drop is partnering with our customers and clinics nationwide to ensure every single person in America diagnosed with diabetes has the insights, information, and support they need to succeed. For every single subscription we sell in the US, whether through payers, employers, health systems or direct to consumers, One Drop will donate 10 One Drop | Experts subscriptions to those most in need, without limitations.”

One Drop | Experts is a clinically-validated, scalable diabetes education and coaching program delivered entirely through the One Drop | Mobile app. It is the first and only digital coaching program to receive ADA recognition, identifying One Drop | Experts as meeting the National Standards for Diabetes Self-Management Education and Support (NSDSMES). The “Experts” are Certified Diabetes Educators (CDEs) who work one-on-one with people with diabetes, providing personalized educational content and insights, as well as ongoing support, encouragement and accountability. One Drop | Experts are available 24/7, delivering all content and advice via in-app chat anytime, anywhere and without prescriptions, hassles, or appointments.

One Drop | Experts has proven to be uniquely engaging, combining the use of mobile technology, real-time health data and human support to empower people with diabetes to take an active role in self-care and achieve healthier outcomes. Earlier this year at the American Diabetes Association 77th Scientific Sessions, Evidation Health Inc. reported results of a study evaluating the One Drop | Mobile app and One Drop | Experts coaching service. In just 3 months, people with type 2 diabetes improved their A1c by [1]:

• -0.90% among study completers;
• -1.00% among active users who used the app and messaged a coach at least once; and
• -1.32% among active users with baseline A1c ≥ 9.0%.

Leveraging data collected in-app, One Drop reported these users [2]:

• reduced carbohydrate intake by >10 grams per meal;
• increased activity by 25 minutes per week;
• decreased average blood glucose by 29 mg/dL (a 1.00% A1c reduction);
• reduced glycemic variability; and
• increased the percentage of in-range blood glucose values.

To learn more about the Power of 10, visit http://onedrop.today/powerof10.

[1] Kumar S., et al. Impact of a diabetes mobile app with in-app coaching on glycemic control. Late-breaking peer-reviewed poster presentation at the 77th Annual Meeting of the American Diabetes Association; San Diego, CA, USA, June 2017.
[2] Osborn C.Y., et al The One Drop mobile app with in-app coaching improves blood glucose and self-care. Peer-reviewed poster presentation at the 77th Annual Meeting of the American Diabetes Association; San Diego, CA, USA, June 2017.

ABOUT ONE DROP
One Drop (Informed Data Systems Inc.) is a digital health company harnessing the power of mobile computing and data science to transform the lives of everyone with diabetes worldwide.

The One Drop platform is evidence-based and clinically effective. It brings affordable, accessible diabetes care to everyone with diabetes and a smartphone, as well as their insurers and health care providers. One Drop’s current offerings include:

One Drop | Chrome: One Drop’s FDA-approved, CE-certified Bluetooth wireless blood glucose monitoring system, which meets the highest standards of clinical accuracy and wirelessly transmits blood glucose data to the cloud via the One Drop | Mobile app for iOS and Android.

One Drop | Plus: One Drop’s newest subscription offerings, providing 50 to 100 blood glucose test strips per month for One Drop | Chrome and unlimited coaching via One Drop | Experts, starting at $13 per month.

One Drop | Premium: One Drop’s unlimited subscription, providing unlimited blood glucose test strips for One Drop | Chrome and unlimited coaching via One Drop | Experts, starting at $33 per month.

One Drop | Experts: One Drop’s 24/7, on-demand, digital diabetes education and coaching service, available as a standalone subscription, starting at $11 per month.* Each One Drop | Experts subscriber has his/her own “Expert” (Certified Diabetes Educator) available 24/7 for guidance, support, and anytime care. Experts deliver personalized digital therapeutics programs, including ADA-recognized diabetes education, to help people with diabetes define and achieve their health management goals. Subscribers can communicate with their Experts anytime via in-app chat; all data recorded in the app is available to Experts in real-time, allowing them to provide personalized behavioral guidance when subscribers need it most — no appointments necessary.

One Drop | Mobile: One Drop’s free, award-winning, cloud-based diabetes management solution delivered entirely via mobile app on iOS and Android. One Drop | Mobile provides real-time and historical blood glucose data and analytics to people with diabetes and their healthcare providers, allowing both to see relationships between specific health behaviors and health outcomes. One Drop | Mobile includes a fully-featured Apple WatchOS app for logging and analyzing diabetes data on the go. One Drop | Mobile is the only diabetes management platform that offers comprehensive self-care, peer-support, and expert support all in one place.

One Drop | Professional: One Drop’s HIPPA-compliant enterprise solution for insurers, healthcare provider networks, self-insured employers, and drug/device manufacturers seeking to dramatically improve health outcomes and lower the cost of caring for people with diabetes. One Drop | Professional delivers real-time data, real-time messaging, custom branding, custom content delivery, custom educational support, EMR/EHR integration, and the most affordable, effective, turnkey diabetes solution in market.

One Drop | Chrome is sold exclusively by One Drop (iOS,Android, and http://onedrop.today/), Amazon (http://www.amazon.com), and Apple (http://store.apple.com). One Drop’s consumer subscription services are available for purchase in-app (iOS andAndroid) and at http://onedrop.today. The One Drop | Mobile solution is available for free download worldwide (iOS andAndroid). For more information, contact just@onedrop.today.

*The American Diabetes Association recognizes this education service as meeting the National Standards for Diabetes Self-Management Education and Support.

Press Contact:
Rachel M. Sanchez
rachel@onedrop.today

ONE DROP REPORTS DRAMATIC A1C REDUCTION AMONG PEOPLE WITH DIABETES USING ONE DROP | MOBILE APP

One Drop | Mobile & Lower A1C

Company announces study results demonstrating a 1.1% to 1.3% absolute reduction in A1C among people with diabetes (type 1 and type 2) using the One Drop | Mobile app.

New York, NY — August 25, 2017 — One Drop today announced the results of a retrospective study of people with diabetes (type 1 and type 2) using the One Drop | Mobile diabetes management app, demonstrating a 1.1% to 1.3% absolute reduction in A1C in just 4 months. The results were published yesterday, August 24, 2017, in JMIR Diabetes.

The One Drop | Mobile app for iOS and Android is available for free in the App Store or Google Play Store. With One Drop | Mobile, users can manually and passively (via Apple HealthKit, Google Fit, and the One Drop | Chrome blood glucose meter) store, track, and share data. Users can schedule medication reminders, view statistics, set goals, track A1c and weight, get data-driven insights, provide and receive encouragement from other users, and get tips and advice to assist with diabetes management.

Using retrospective app-collected data, One Drop in collaboration with U.S. and non-U.S.-based scientists, assessed the A1c change of people using One Drop | Mobile. They also assessed the relationship between tracking self-care with the app and changes in A1c.

One Drop A1C drop for T2Ds
One Drop A1C drop for T1Ds

“We used real-world data to produce timely and relevant results,” said Dr. Chandra Osborn, Vice President of Health and Behavioral Informatics at One Drop. “More often than not, relevance and the gold standard randomized controlled trial are at odds. We didn’t perform a RCT on outdated technology. We studied current technology and recent data, and found A1c improved among people using the One Drop app. We also linked that improvement to tracking self-care with the app.” Dr. Osborn added, “From study to publication in less than 3 months is unheard of. That’s impossible to do with a RCT. When it comes to technology, relevance and speed are everything.”

As of June 7, 2017, 1288 people with type 1 or type 2 diabetes had entered two A1c values in the app (from 2 to 12 months apart), had their diabetes diagnoses verified with medications entered in the app, and had an average blood glucose consistent with their self-reported A1c values. Of the 367 people with type 1 diabetes and 921 people with type 2 diabetes, 35% were female, diagnosed with diabetes for a mean 9 years, and tracked an average 1700 self-care activities in the app between their two A1c values. Self-reported A1c can be as accurate as laboratory A1c [1], and we confirmed self-reported A1c was significantly associated with 90-day average blood glucose (rho=.73 to .75, P<.001) and consistent with cohort studies testing the relationship between blood glucose and laboratory A1c. During a median of 4 months, the following outcomes were observed [2]:

  • A1c improved by -1.1% (from 8.3% to 7.2% in adjusted analyses, P<.001) across all users studied.
  • A1c improved by -1.3% (from 8.3% to 7.0%, P<.001) for users with T2D.
  • A1c improved by -0.9% (from 8.4% to 7.5%, P<.001) for users with T1D.
  • In unadjusted and adjusted analyses, using One Drop | Mobile to record food was associated with greater A1c improvement (all models, P<.05).

“Prior to this study, the scientific literature told us that diabetes mobile apps could potentially improve A1c by -0.45%,” said Jeff Dachis, CEO and Founder of One Drop. “I’m thrilled to present evidence that says otherwise. We are seeing dramatic improvements in A1c — often achieved with drugs, but rarely, if ever, seen with digital therapeutics and self-care interventions. And, in this case, we’re doing it all at scale for less than a fraction of the cost of current standards of care: free.”

At this year’s American Diabetes Association 77th Scientific Sessions, Evidation Health Inc. reported results of a non-randomized study evaluating the One Drop | Mobile app and One Drop | Experts coaching service. In only 3 months, people with T2D improved their A1c by [3]:

  • -0.90% among study completers;
  • -1.00% among active users who used the app and messaged a coach at least once; and
  • -1.32% among active users with baseline A1c ≥ 9.0%.

Leveraging data collected in-app, One Drop reported these users [4]:

  • reduced carbohydrate intake by >10 grams per meal;
  • increased activity by 25 minutes per week;
  • decreased average blood glucose by 29 mg/dL (a 1.00% A1c reduction);
  • reduced glycemic variability; and
  • increased the percentage of in-range blood glucose values.

“With growing numbers of people developing diabetes and increasing options to treat the disease, self-management has become much more complex,” said Dr. David Marrero, Director of the Center for Health Disparities Research at the University of Arizona and former President of the American Diabetes Association’s Healthcare and Education. “The One Drop | Mobile app illuminates the potential for mobile technology to assist persons with diabetes in both tracking the varied elements of their therapy and making more informed self-management decisions. Too many apps promise to improve health, but often don’t deliver. It’s great to see an app that finally does.”
_______________
1 Kumar S, Uppal J, Osborn CY, Heyman M, Juusola J. The accuracy of self-reported A1c among individuals with type 2 diabetes. 2017 Diabetes Abstract Book, vol 67 (Suppl 1A), Late Breaking.
2 Osborn CY, van Ginkel JR, Rodbard D, Heyman M, Marrero DG, Huddleston B, Dachis J, One Drop | Mobile: An Evaluation of Hemoglobin A1c Improvement Linked to App Engagement, JMIR Diabetes 2017;2(2):e21, http://diabetes.jmir.org/2017/2/e21/, doi: 10.2196/diabetes.8039.
3 Kumar S., et al. Impact of a diabetes mobile app with in-app coaching on glycemic control. Late-breaking peer-reviewed poster presentation at the 77th Annual Meeting of the American Diabetes Association; San Diego, CA, USA, June 2017.
4 Osborn C.Y., et al The One Drop mobile app with in-app coaching improves blood glucose and self-care. Peer-reviewed poster presentation at the 77th Annual Meeting of the American Diabetes Association; San Diego, CA, USA, June 2017.

ABOUT ONE DROP
One Drop (Informed Data Systems Inc.) is a digital health company harnessing the power of mobile computing and data science to transform the lives of everyone with diabetes worldwide.

The One Drop platform is evidence-based and clinically effective. It brings affordable, accessible diabetes care to everyone with diabetes and a smartphone, as well as their insurers and health care providers. One Drop’s current offerings include:

One Drop | Chrome: One Drop’s FDA-approved, CE-certified Bluetooth wireless blood glucose monitoring system, which meets the highest standards of clinical accuracy and wirelessly transmits blood glucose data to the cloud via the One Drop | Mobile app for iOS and Android.

One Drop | Plus: One Drop’s newest subscription offerings, providing 50 to 100 blood glucose test strips per month for One Drop | Chrome and unlimited coaching via One Drop | Experts, starting at $13 per month.

One Drop | Premium: One Drop’s unlimited subscription, providing unlimited blood glucose test strips for One Drop | Chrome and unlimited coaching via One Drop | Experts, starting at $33 per month.

One Drop | Experts: One Drop’s 24/7, on-demand, digital diabetes education and coaching service, available as a standalone subscription, starting at $11 per month.* Each One Drop | Experts subscriber has his/her own “Expert” (Certified Diabetes Educator) available 24/7 for guidance, support, and anytime care. Experts deliver personalized digital therapeutics programs, including ADA-recognized diabetes education, to help people with diabetes define and achieve their health management goals. Subscribers can communicate with their Experts anytime via in-app chat; all data recorded in the app is available to Experts in real-time, allowing them to provide personalized behavioral guidance when subscribers need it most — no appointments necessary.

One Drop | Mobile: One Drop’s free, award-winning, cloud-based diabetes management solution delivered entirely via mobile app on iOS and Android. One Drop | Mobile provides real-time and historical blood glucose data and analytics to people with diabetes and their healthcare providers, allowing both to see relationships between specific health behaviors and health outcomes. One Drop | Mobile includes a fully-featured Apple WatchOS app for logging and analyzing diabetes data on the go. One Drop | Mobile is the only diabetes management platform that offers comprehensive self-care, peer-support, and expert support all in one place.

One Drop | Professional: One Drop’s HIPPA-compliant enterprise solution for insurers, healthcare provider networks, self-insured employers, and drug/device manufacturers seeking to dramatically improve health outcomes and lower the cost of caring for people with diabetes. One Drop | Professional delivers real-time data, real-time messaging, custom branding, custom content delivery, custom educational support, EMR/EHR integration, and the most affordable, effective, turnkey diabetes solution in market.

One Drop | Chrome is sold exclusively by One Drop (iOS, Android, and http://onedrop.today/), Amazon (http://www.amazon.com), and Apple (http://store.apple.com). One Drop’s consumer subscription services are available for purchase in-app (iOS and Android) and at http://onedrop.today. The One Drop | Mobile solution is available for free download worldwide (iOS and Android). For more information, contact just@onedrop.today.

*The American Diabetes Association recognizes this education service as meeting the National Standards for Diabetes Self-Management Education and Support.

 

MannKind and One Drop Partner to Launch the A-One Clinical Trial

MannKind One Drop Partnership

Study will utilize Afrezza® inhaled insulin and the One Drop digital diabetes care platform

NEW YORK, NY and VALENCIA, CA. — August 7, 2017 (GLOBE NEWSWIRE) —MannKind Corporation (Nasdaq:MNKD) (TASE:MNKD) and One Drop today announced the first step of their collaboration with the launch of the A-ONE study, a randomized controlled trial investigating the use of Afrezza® inhaled insulin and One Drop’s integrated digital diabetes care platform.

In May 2017, MannKind and One Drop announced a memorandum of understanding to explore collaborations related to One Drop | Premium (i.e., One Drop | Mobile app, One Drop | Chrome meter and test strips, One Drop | Experts coaching service) and Afrezza®, MannKind’s inhaled rapid-acting mealtime insulin. One goal of the collaboration is to identify ways of simplifying the complexity of starting and staying on mealtime insulin along with Customized Coaching to help people achieve their A1C goals.

Appropriate people with type 2 diabetes who meet inclusion criteria will be randomized to one of two treatment arms: Afrezza® with One Drop | Premium – or – One Drop | Premium alone. Changes in hemoglobin A1C, quality of life, self-care, treatment satisfaction, and other metrics will be assessed. People with type 2 diabetes interested in learning more should email Aone@onedrop.today.

Dr. Raymond Urbanski, Chief Medical Officer of MannKind Corporation, said, “This study is intended to evaluate whether combining a solutions-oriented digital disease management platform like One Drop with an innovative drug like Afrezza® will provide patients with an improved ability to manage their diabetes.”

“One Drop is a unique, fully integrated solution with the prospects of a huge health benefit,” says Dr. Chandra Osborn, VP of Health and Behavioral Informatics at One Drop. “We know each piece of the puzzle works, and now we want to see how well they work together. With 9 peer-reviewed outcomes shared at medical meetings and a paper in press at JMIR Diabetes, One Drop is committed to delivering the most effective diabetes management solution in the market. The combination of One Drop with inhaled insulin could offer consumers, health care providers, and payers a potentially powerful solution with unprecedented benefits.”

“Diabetes technology is evolving in a very exciting way,” said Jeff Dachis, CEO and Founder of One Drop. “But not surprisingly for the vast majority of people with diabetes worldwide, expensive sensors, automated insulin delivery solutions, or call center approaches to care can create barriers and challenges to effective disease management. However, we are excited to evaluate whether a completely integrated digital diabetes therapeutics platform — encompassing evidence-based interventions, ADA-recognized diabetes education and coaching, wireless blood glucose tracking, user-centered design, robust data science, and an innovative pharmaceutical product like MannKind’s Afrezza — can deliver improved health outcomes at a fraction of the cost of current standards of care.”

At this year’s American Diabetes Association 77th Scientific Sessions, Evidation Health Inc. reported results of a non-randomized study evaluating the One Drop | Mobile app and One Drop | Experts coaching service. In only 3 months, people with type 2 diabetes reduced their A1c by [1]:

• .90% among study completers
• 1.00% among active users who used the app and messaged a coach at least once
• 1.32% among active users with baseline A1c ≥ 9.0%

Leveraging data collected in-app, One Drop reported that these users [2]:

• reduced carbohydrate intake by >10 grams per meal;
• increased activity by 25 minutes per week;
• decreased average blood glucose by 29 mg/dL (a 1.00% A1c reduction);
• reduced glycemic variability; and
• increased the percentage of in-range blood glucose values.

_______________
1 Kumar S., et al. Impact of a diabetes mobile app with in-app coaching on glycemic control. Late-breaking peer-reviewed poster presentation at the 77th Annual Meeting of the American Diabetes Association; San Diego, CA, USA, June 2017.
2 Osborn C.Y., et al The One Drop mobile app with in-app coaching improves blood glucose and self-care. Peer-reviewed poster presentation at the 77th Annual Meeting of the American Diabetes Association; San Diego, CA, USA, June 2017.

ABOUT MANNKIND CORPORATION

MannKind Corporation (TASE:MNKD) focuses on the discovery, development and commercialization of therapeutic products for patients with diseases such as diabetes. MannKind maintains a website at www.mannkindcorp.com to which MannKind regularly posts copies of its press releases as well as additional information about MannKind. Interested persons can subscribe on the MannKind website to e-mail alerts that are sent automatically when MannKind issues press releases, files its reports with the Securities and Exchange Commission or posts certain other information to the website. For more information on Afrezza, please visit www.afrezza.com.

ABOUT ONE DROP

One Drop (Informed Data Systems Inc.) is a digital health company harnessing the power of mobile computing and data science to transform the lives of everyone with diabetes worldwide.

The One Drop platform is evidence-based and clinically effective. It brings affordable, accessible diabetes care to everyone with diabetes and a smartphone, as well as their insurers and health care providers. One Drop’s current offerings include:

One Drop | Chrome: One Drop’s FDA-approved, CE-certified Bluetooth wireless blood glucose monitoring system, which meets the highest standards of clinical accuracy and wirelessly transmits blood glucose data to the cloud via the One Drop | Mobile app for iOS and Android.

One Drop | Plus: One Drop’s newest subscription offerings, providing 50 to 100 blood glucose test strips per month for One Drop | Chrome and unlimited coaching via One Drop | Experts, starting at $13 per month.

One Drop | Premium: One Drop’s unlimited subscription, providing unlimited blood glucose test strips for One Drop | Chrome and unlimited coaching via One Drop | Experts, starting at $33 per month.

One Drop | Experts: One Drop’s 24/7, on-demand, digital diabetes education and coaching service, available as a standalone subscription, starting at $11 per month.* Each One Drop | Experts subscriber has his/her own “Expert” (Certified Diabetes Educator) available 24/7 for guidance, support, and anytime care. Experts deliver personalized digital therapeutics programs, including ADA-recognized diabetes education, to help people with diabetes define and achieve their health management goals. Subscribers can communicate with their Experts anytime via in-app chat; all data recorded in the app is available to Experts in real-time, allowing them to provide personalized behavioral guidance when subscribers need it most — no appointments necessary.

One Drop | Mobile: One Drop’s free, award-winning, cloud-based diabetes management solution delivered entirely via mobile app on iOS and Android. One Drop | Mobile provides real-time and historical blood glucose data and analytics to people with diabetes and their healthcare providers, allowing both to see relationships between specific health behaviors and health outcomes. One Drop | Mobile includes a fully-featured Apple WatchOS app for logging and analyzing diabetes data on the go. One Drop | Mobile is the only diabetes management platform that offers comprehensive self-care, peer-support, and expert support all in one place.

One Drop | Professional: One Drop’s HIPPA-compliant enterprise solution for insurers, healthcare provider networks, self-insured employers, and drug/device manufacturers seeking to dramatically improve health outcomes and lower the cost of caring for people with diabetes. One Drop | Professional delivers real-time data, real-time messaging, custom branding, custom content delivery, custom educational support, EMR/EHR integration, and the most affordable, effective, turnkey diabetes solution in market.

One Drop | Chrome is sold exclusively by One Drop (iOS, Android, and http://onedrop.today/), Amazon (http://www.amazon.com), and Apple (http://store.apple.com). One Drop’s consumer subscription services are available for purchase in-app (iOS and Android) and at http://onedrop.today. The One Drop | Mobile solution is available for free download worldwide (iOS and Android). For more information, contact just@onedrop.today.

*The American Diabetes Association recognizes this education service as meeting the National Standards for Diabetes Self-Management Education and Support.

MannKind Contact:
Rose Alinaya SVP, Investor Relations
661-775-5300
IR@mannkindcorp.com

One Drop Contact:
Rachel M. Sanchez
917-342-2892
rachel@onedrop.today

Empowerment through Technology: How do we get there?

Technology & Empowerment

The diabetes technology and digital space is booming and nowhere was this more clear than at the American Diabetes Association’s Scientific Sessions held this past June in San Diego. From the exhibit hall and poster sessions to the buzz in the hallway, you couldn’t walk 10 feet without seeing something about diabetes technology.

As I listened to what people are saying about technology, I heard a lot of buzzwords and phrases like ‘engagement’, ‘make life with diabetes easier’ and ’empowerment’. It’s true and really exciting. If designed and delivered well, digital health and technology can empower people in their own self-care.

But we have to be careful to make sure these technologies empower people to make healthy choices in their diabetes management and not become disengaged from the link between their behavior and their health.

What does empowerment mean?

Empowerment means the process of becoming stronger and more confident, especially in controlling one’s life. It’s the ability to be mindful and make healthy choices and having the tools and skills needed to act on these choices. Technologies help empower people with diabetes in many ways, especially by giving them data, tools and support, which can be used to increase motivation to be active in their health.

For example, seeing diabetes data can clearly show you the impact that some of your decisions have on your blood sugar, like if you drink a regular soda, it will make your blood sugar go up. Digital health can give people with diabetes tools and teach them skills they can use to actually change their behavior. These technologies also increase access to the support that’s essential to helping people make changes. Having a choice by definition means there is more than one path you can take. Empowering people to make a healthy choice with diabetes doesn’t necessarily make the choice easy, rather it helps them make the healthy choice even though it may not be easy.

I’ll be honest here. Some of the ways that people were talking about technology at ADA made me a little nervous. For example, some folks were describing closed loop and artificial pancreas systems as technologies that will completely automate diabetes management, meaning people who use them won’t ever have to think about diabetes. These tools promise to make diabetes easier and lighten some of the load that people with diabetes have to carry.

Diabetes, Technology & Empowerment

But…

We are doing ourselves a great disservice if we let technology, or our expectations of it, disempower us. Diabetes is a serious condition and living a healthy lifestyle, including taking insulin and other medications as prescribed, is at the center of good diabetes management. We are fooling ourselves if we believe that managing diabetes doesn’t take hard work. We are not doing ourselves any good if we believe that technology can make hard work unnecessary.

If we aren’t careful in the way we talk about and use diabetes technology and digital health tools, we run the risk of becoming disempowered. Empowerment doesn’t mean easy or mindless, rather it means strong and mindful. Empowerment means that when you are faced with a decision, you have the tools you need to make a healthy one, as opposed to making an easy (and often unhealthy) choice and letting technology cover for you.

So, what does empowerment through technology look like?

At One Drop, we truly believe that empowering people in their health is the key to diabetes management. Everything that we do gives people the tools they need to become more mindful, motivated and empowered to manage diabetes well. No matter what technology we use to manage diabetes, whether it’s a closed-loop artificial pancreas system or just an insulin pen/pills,  we should always be mindful of the impact our behaviors have on our health outcomes.

We know that diabetes management takes focus and hard work, and we know this isn’t always easy. We’re committed to giving people the information, tools and support they need to lean into this hard work and be successful because that is the only way we’ll have a lasting impact our health. Any other way is just a band-aid on a broken bone.

Goodbye Professor, Hello Startup.

Chandra Osborn PhD, MPH

I tend to forge my own path. I was the first in my family to go to college. I got a masters degree, a PhD, a second masters degree, and, finally my dream job: a tenure-track position at a prestigious university.

For 8 years, I was a professor, NIH-funded scientist, and sought after advisor. I led clinical trials and published over 90 peer-reviewed papers. I taught, mentored students, residents, post-docs, and junior faculty. I held national leadership positions. I led a team of bright and talented people doing, what often felt like, impossible health tech research. And I was right on the cusp of being tenured (i.e. I’d have job security until retirement).

Then, I did something I thought I’d never do: I walked away from it all.

I left prestige. I left my research, my team, and my mentees. I also walked away from a huge college benefit for my kids (70% off tuition at my university or 100% off if at a cheaper college anywhere in the country!). Not many people walk away from a highly-coveted academic position or from tenure they’re about to touch. If they do, it’s for another university offering the same benefits, if not more. Instead, I left for a startup, where nothing is guaranteed.

Say what?

I’M NOT ALONE

Before starting my new job, I read an article in the New York Times. It was about economists leaving prestigious universities to join Facebook, Microsoft, Amazon, Uber and Airbnb.

So, why are people leaving academia? A few reasons:

Less bureaucracy. Academics spend more time jumping hurdles than getting their work done. Tech companies don’t have that red tape.

Big data. Academics waste time, money, and resources to collect enough data to say something interesting. Tech companies collect endless amounts of data by default and need people to leverage that data in meaningful ways.

Impact. In academia, people wait too long for their research findings to change the world. Tech companies move fast to impact the world today. #wearenotwaiting

WHY DID I BECOME A PROFESSOR?

I became a professor and scientist to help people. I wanted to discover, understand, mentor, and have a profound impact. I wanted to help people live healthier and happier lives.

For 15 years, I studied how to promote health. I built and tested health programs for people with diabetes. I wanted these programs to work and help as many people as possible.

But they helped only people in my research trials, and no one else. Why? Because it takes 17 years for research findings to have any impact in the real world, if at all. That’s just — Way. Too. Long.

DELIVERY MATTERS

Before 2008, I delivered health promotion in the most low-tech ways, with flip-charts, printed materials, and people — like community health workers, dietitians and certified diabetes educators. But in 2008, I realized the world was headed in a different direction.

As I held my first smartphone in my hands, I asked myself: “How can I use this technology to help people manage their health? And how can I do it more effectively and at greater scale?”

Health apps were just gaining traction, and developing one seemed out of reach for me and my small team. So, we built a website instead.

TECHNOLOGY MOVES FAST & ACADEMIA CAN’T KEEP UP

We built Diabetes MAP, a website to help people stick to their medication schedule, and spent years studying it. But, what you won’t find in my research articles is all the challenges we faced building Diabetes MAP. It was complicated, delayed, and frustrating.

My colleagues at other universities all agree: developing health tech in academia is slow and painful. It’s impossible to hire and retain the best and the brightest graphic designers, developers, and tech project managers. Some of the reasons for this:

They’re underpaid. Tech people can easily make six figures in the commercial world. In academia, you only make that much if you have a MD or PhD.

The environment stifles creativity. Tech people would rather work in creative environments and around like-minded people — in coffee shops or co-working spaces with others like them. Being bound to a cubicle from 9-5 doesn’t appeal to them, or anyone for that matter.

They want to use modern tools. Tech people expect to use the latest tools to get sh*t done. Tools like Slack, Trello, Basecamp, and Jira, instead of landlines, Outlook, or pagers (yes, these things still exist!).

THE RESULT?

Health tech innovations in academia are bootstrapped together, break, and have to be rebuilt over and over again. More headache, more expense, and more time… I came up with the idea of Diabetes MAP in early 2009, and it took 8 years to complete our research on it!

In those eight years, there were 15 versions of the iPhone, the launch of the iPad, the launch of the Apple Watch, and multiple versions of Android and PC. In 2009, a website seemed innovative and worth our time and resources. But, by the time we built and rebuilt it (three times!), and learned if it worked, people had moved on. What might’ve engaged people in 2009 is obsolete today. Today, Diabetes MAP would absolutely be an app, and not a website.

ENGAGEMENT IS LOW

Engagement (e.g. responding to a website or app by opening it, clicking around, and coming back) in academic-made technologies is low. We don’t make technologies people want to use. It’s not our skill set. It’s not what we’ve been trained to do.

To develop apps and websites people love, academics have to work with people who DO know how to use technology to engage people: Graphic designers. Software developers. Tech project managers. People who understand design, development, and engagement, but don’t necessarily know how to use those skills to improve health behaviors and health outcomes. We need to team up for the magic to happen.

#IMNOTWAITING

I’m hopeful the academic landscape will change… but, I just can’t wait.

Ten months ago, I left an academic dream job, a team of people and mentees I love, and a near-guarantee of tenure to join a health tech startup.

Why? Because they’re a team of people who understand design, development, and engagement and want players like me on deck to help improve health behaviors and health outcomes. We’re using the latest technologies to make managing diabetes simple, awesome, cost-effective, evidence-based… and we’re doing it right now.

LIFE AFTER ACADEMIA

Early On

The startup I work for is in NYC. I now travel to/from NYC one week per month, leaving my 2-year-old and 5-year-old at home in Nashville.

I work at a co-working space in a small room with 10 other people. I no longer have a corner office with an executive desk, 3 computer monitors, a Herman Miller chair, an administrative assistant, or an army of people doing things for me at the drop of a hat. It’s a lot different.

When I got back to Nashville after my first week in NYC, my husband wanted to hear all about it. “Well, I was the first in the office each day. Most get in at 10. The building’s water was out, so the toilets were plugged up. I went to the closest pharmacy to get a case of water and lugged it back to the team. Our tiny open space means we all get to listen to each others’ conversations, including contentious ones. And, finally, I have no idea what I’m doing beyond writing blog posts.”

The truth is, it took time for me to adjust.

Today

Ten months later, I love what I’m doing. The pace is fast. The impact is faster, anecdotally and empirically.

One Drop is the startup I work for. One Drop’s products include a mobile app (One Drop | Mobile) with in-app coaching (One Drop | Experts) and a sexy glucose meter (One Drop | Chrome). One Drop is supporting the health and wellness of people with diabetes around the world. I was recently analyzing over 1 million pieces of raw data generated in one week’s time, and hyper aware of the awesomeness of how that data landed in my lap, instantly.

Just today, another user reached out to say he lowered his hemoglobin A1c from 14% (19.7 mmol/mol) to 6% (7 mmol/mol) in just four months. This is profound impact, but not unique. Favorable anecdotal feedback pours in, all. day. long. Such a gift!

Another gift is doing science – just faster. We’ve generated 8 peer-reviewed scientific abstracts (4 in press), have multiple manuscripts under review, and much more on the way. At the recent Society of Behavioral Medicine meeting we reported people using the One Drop | Mobile app with and without One Drop | Experts have dramatic blood glucose improvements.

The American Diabetes Association’s 77th Scientific Sessions start this week. We’ll be presenting exciting outcomes of an internal and external evaluation of the One Drop | Mobile app + One Drop | Experts program. The embargo lifts on June 10th, so stay tuned.

A REMINDER…

Two months after I left academia, a big box arrived at my doorstep. It was a gift from my former university. A wooden chair embossed with the university’s seal and a gold plate engraved with: “Wishing you the best from your colleagues.” It’s a chair given only after 25 years of service. I’m grateful for the thoughtful gesture. But, the chair is hard, uncomfortable, and reminds me of Diabetes MAP: another thing no one will ever use.

Vanderbilt Chair

Mobile Health is the Solution: Pearls from experts in diabetes & minority health

Experts in Diabetes & Minority Health

Studies suggest tablet-, app-delivered, and text messaging programs improve self-care and glycemic control. Most programs are tested with people who are more affluent, educated, and White. Few have been designed for and tested with more high-risk groups who are more likely to have diabetes and its consequences.

The recent Society of Behavioral Medicine meeting brought together behavioral scientists in industry and academia with expertise in diabetes, tech, and minority health. As one of them, I chaired a session on “Leveraging technology to support vulnerable and disadvantaged people with diabetes: A review, examples, and recommendations.”

Pearls from experts in diabetes, tech, and minority health

Dr. Monica Peek is Associate Professor of Medicine & Associate Director of the Center for Diabetes Translational Research at the University of Chicago. She’s leveraged technology to improve diabetes care and medical outcomes for people with diabetes on the South Side of Chicago. Dr. Peek presented a review of research on digital programs for people with diabetes who were of low socioeconomic status, a member of a minority group, or had limited literacy/numeracy skills.

    • She reported 11/12 text messaging intervention studies published from 2010-2015 reported glycemic control improvements.
    • Few had a control group needed for causal conclusions.
    • According to Dr. Peek, “A tailored digital touch with a human touch and coaching appears to work best.”

Dr. Lindsay Mayberry is Assistant Professor of Medicine at Vanderbilt University Medical Center. When I left Vandy to join One Drop, Dr. Mayberry took over my NIH-funded trial evaluating a text messaging program for people with type 2 diabetes in safety-net clinics throughout Nashville, TN. Dr. Mayberry presented that trial’s 3 arm design: (1) non-tailored text messages, (2) tailored text messages, (3) tailored text messages with coaching.

    • The trial requires daily engagement for 9 months. At 3 and 6 months, over 80% of participants are engaged.
    • According to Dr. Mayberry, “We attribute high rates of engagement to sending participants hand-written birthday cards, swag, monthly newsletters with recipes, expert advice, and research findings.”
    • “The experience of being a research participant must be ultra-personalized. When you care, you have to show it.”

CYO-mobileHealth-bodyDr. Courtney Lyles is Assistant Professor of Internal Medicine at UCSF’s San Francisco General Hospital and Center for Vulnerable Populations. She’s using tech to improve patient-provider communication, diabetes self-management, and reduce disparities in health. Dr. Lyles used tablets and user-centered design strategies to improve the experience of completing forms and answering questions during clinic intake.

    • She iteratively worked with users to simplify and make visual patient questions and response options.
    • The adaptation process resulted in high rates of satisfaction and completion rates.

Dr. Brian Oldenburg is Professor and Chair of Non-Communicable Disease Control and the Director of the Centre for Health Equity in the Melbourne School of Population and Global Health at the University of Melbourne. His work has led the way (inter)nationally in the development and evaluation of new technologies and mobile programs to improve health. Dr. Oldenburg was the discussant of this session.

    • According to Dr. Oldenburg, “More digital diabetes programs should be developed and evaluated in lower and middle-income countries.”
    • He also acknowledged, “Developing digital diabetes programs everyone can access & use is really challenging.”
    • All speakers and attendees nodded in unison.

Experts in diabetes and minority health

Cell phones let us reach everyone

Cell phones are ubiquitous and powerful. People in lower and middle income countries use them. People in higher income countries at highest risk of diabetes and everything that follows use them too. Apps like One Drop are delivering education, support, strategies, and tools to keep people healthy.

We need to make sure everyone who needs diabetes education and support gets it. Only then can we reduce diabetes disparities, and their human and economic burden.