What Causes Insulin Resistance?

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But First: What Is Insulin Resistance?

Insulin is often referred to as “the most powerful hormone” in the body of any mammal — including humans. Without it, we wouldn’t be able to convert the glucose (sugar) in our bloodstream in order to use it for energy. (Read all about insulin here!)

If we can’t convert it to use for energy, it sits in our bloodstream. And as it sits, that glucose builds to higher blood sugar levels, which can lead to severe complications and even death if left untreated.

Insulin resistance is a state in the body in which the body needs more insulin than “normal” in an effort to maintain healthy blood sugar levels.

As the degree of insulin resistance increases, the body’s demand for more insulin can surpass what the pancreas can actually produce.

That increasing need for more insulin can lead to weight gain, high blood sugars, pre-diabetes, and type 2 diabetes.

> Read About Type 2 Diabetes Here! <

“The person's body may not be producing enough insulin to meet their needs, so some glucose can't get into the cells,” explains the Joslin Diabetes Center.

“Glucose remains in the bloodstream, causing high blood glucose levels. In many cases, the person may actually be producing more insulin than one might reasonably expect that person to need to convert the amount of food they've eaten at a meal into energy.”

Eventually, the pancreas begins working “overtime” to produce more and more insulin, while the body’s cells continue to be “resistant to the effects of insulin.”

“Basically the cells, despite the presence of insulin in the bloodstream, don't become unlocked and don't let enough of the glucose in the blood into the cells,” Joslin goes on to explain.

What Causes Insulin Resistance? 

While mainstream media oftentimes oversimplifies insulin resistance as a self-induced cause of type 2 diabetes, the cause of it is actually much more complex, and still somewhat of a mystery.

“In people with type 2 diabetes, a combination of problems occurs, and scientists aren't really sure which is the chicken, and which is the egg,” explains the Joslin Diabetes Center.

“Scientists don't know exactly what causes this insulin resistance, and many expect that there are several different defects in the process of unlocking cells that cause insulin resistance.”

Generally, however, there are several known factors that worsen and contribute to a person’s insulin sensitivity and resistance levels:

➣ Weight gain and being overweight

➣ A sedentary lifestyle and lack of exercise

Sleep apnea and other sleep problems

➣ A diet consisting primarily of processed foods and fast-food

➣ Air pollution

➣ Excessive estrogen production

➣ Smoking cigarettes

➣ Certain diseases (like PCOS) or treatments for those diseases (like medications used to treat cystic fibrosis)

➣ Steroids (like prednisone and cortisol)

➣ Old age

“71 percent of people with type 2 diabetes have been diagnosed with sleep apnea,” says Jody Stanislaw, ND, CDE. Dr. Stanislaw has lived with type 1 diabetes since childhood.

Who Can Develop Insulin Resistance?

Insulin resistance is often the catalyst in the development of type 2 diabetes and obesity. However, anyone can experience varying levels of insulin resistance, and it doesn’t necessarily mean you’ll develop diabetes.

If you’ve experienced a major stressor or life event

Anyone can experience a short-term degree of insulin resistance because of a high-stress phase in their life which increases cortisol production.

If you’ve experienced the death of a loved one, a divorce, a car crash or any other traumatic event, all of these things can lead to increased resistance to insulin.

But that doesn’t necessarily mean you would go on to develop type 2 diabetes. When that phase of stress in your life ends or is reduced, your insulin resistance levels would ideally be reduced, too.

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If you’ve gained a little or a lot of weight

Gaining even 5 pounds will increase your body’s level of insulin resistance.

But that weight gain would generally only cause a problem if the weight continues to pile on.

When a 5-pound weight gain becomes a 30-pound weight gain, and then a 50-pound weight gain, that’s when insulin resistance levels begin to show a significant impact on blood sugar levels.

On the flipside, losing weight (even just 5 or 10 pounds) will reduce your body’s level of insulin resistance, causing you to be more sensitive to insulin.

Heightened insulin sensitivity reduces your overall risk of developing pre-diabetes or type 2 diabetes.

If your lifestyle habits have changed, even temporarily

If you’ve suddenly started eating a pint of ice cream every night or you haven’t been to the gym in three months, you can bet your personal level of insulin resistance has increased.

Your daily lifestyle habits around food and exercise play a major role in how much insulin your body needs to produce in order to maintain healthy blood sugar levels.

However, the length of time you continue those not-so-healthy habits will largely determine if your insulin resistance increases to the point of elevated blood sugar levels, and a possible pre-diabetes or type 2 diabetes diagnosis.

If you eat a diet high in processed carbohydrates

The carbohydrates in a strawberry are not going to impact your body the same as the carbohydrates in a bowl of mac & cheese or Cap'n Crunch.

The more carbohydrates you eat, the more insulin your body needs to produce in order to take the glucose from those digested carbohydrates and convert them into energy.

Even your “healthy” Nutrigrain bar is made with heavily processed carbohydrates. It’s a product, rather than a whole-food source of carbohydrates, like whole oats, rice, legumes, or fruit.

While whole-food sources of carbohydrate still require large amounts of insulin, they provide more fiber, vitamins, and minerals than a heavily processed product.

If you have a certain ethnic background

While anyone of any race or ethnicity can develop insulin resistance, certain ethnicities have shown to be at a much higher risk than others, explains Dr. Stanislaw:

● Asian Americans

● African Americans

● Mexican Americans

● American Indians

● Native Hawaiians

● Pacific Islanders

“94 percent of the children diagnosed with type 2 diabetes [as a result of insulin resistance] are minorities,” adds Dr. Stanislaw.

What Are The Symptoms Of Insulin Resistance?

“The most obvious signs of insulin resistance,” explains Dr. Stanislaw, “are elevated blood pressure levels, elevated cholesterol levels, acanthosis nigricans, and PCOS (polycystic ovarian syndrome).”

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Inexplicable weight gain can also be a symptom for some.

As the Joslin Diabetes Center explains, some people develop an inability to make use of the insulin they produce.

Even if they have healthy habits and are at a healthy weight, that increasing production of insulin can lead to weight gain, which contributes to their overall insulin resistance.

When Does Insulin Resistance Become Prediabetes Or Type 2 Diabetes?

The point at which your level of insulin resistance becomes significant enough to warrant a diagnosis and purposeful treatment is based on your blood sugar levels and your HbA1c (or A1C).

The American Diabetes Association states the following criteria for a diagnosis of prediabetes or type 2 diabetes:


✔︎ A fasting plasma glucose reading between 100 mg/dL to 125 mg/dL

✔︎ An HbA1c result of 5.7 to 6.4 percent

Type 2 Diabetes

✔︎ A fasting plasma glucose reading above 126 mg/dL

✔︎ An HbA1c result of 6.5 percent or higher

While an official diagnosis may be scary and daunting, it’s a crucial sign that it’s time to make changes in your lifestyle habits. Medications may be needed to help increase your body’s natural insulin production.

But before you start on those medications, you have other options to try. Cutting down your carbohydrate intake and instead consuming more proteins, healthy fats, and veggies is a great step in the right direction.

Adding in more cardio and strength training to your daily routine (even weekly!) is another great way to increase insulin sensitivity, thus decreasing insulin resistance.

Even if you've already been diagnosed with diabetes, these two lifestyle habits alone can make major differences on insulin's impact on your body. Give it a shot!

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Ginger Vieira
Feb 05, 2019

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